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What is FAP

Familial Adenomatous Polyposis (FAP) is a hereditary condition that results in the early development of polyps and colorectal cancer that could starts at the early age of 12 years old.

FAP is considered as an orphan disease, with a prevalence of 0,6/1,0 out of 10.000.

Caused by germline mutations in the APC gene it is characterized by the development of hundreds to thousands of polyps and carriers of the APC gene mutation, if not treated appropriately, will develop colorectal cancer. Unfortunately at the moment there is no safe treatment available.

Current “Gold Standard” treatment is a partial or full removal of the colon (colectomy)

Alfa has repeatedly shown a reduction in the number and size of polyps in FAP patients without any side effect.

 

reduction in the number and size of polyps in FAP patients